Encoding Health

Unlocking cures

Developing transformative in vivo genetic medicines
Developing transformative in vivo genetic medicines
Developing transformative in vivo medicines
Abstract illustration of vertical bars in varying lengths and colors, resembling a stylized genetic barcode or DNA sequencing pattern.

Our Science

Stylus Medicine is developing in vivo genetic medicines to unlock cures.
Our platform is powered by engineered recombinases that encode therapeutics with high precision.

Illustration of a DNA molecule and a DNA-binding protein before interaction, with the protein’s binding domain highlighted.
Illustration of a DNA molecule and a DNA-binding protein before interaction, with the protein’s binding domain highlighted.
Illustration of a DNA molecule and a DNA-binding protein before interaction, with the protein’s binding domain highlighted.
Illustration of a DNA-binding protein simultaneously attaching to two sites on the DNA, forming a looped structure through protein-DNA interactions.
Illustration of a DNA-binding protein simultaneously attaching to two sites on the DNA, forming a looped structure through protein-DNA interactions.
Illustration of a DNA-binding protein simultaneously attaching to two sites on the DNA, forming a looped structure through protein-DNA interactions.
Illustration of DNA after cleavage at the looped region, with the DNA-binding protein remaining attached to the separated DNA ends.
Illustration of DNA after cleavage at the looped region, with the DNA-binding protein remaining attached to the separated DNA ends.
Illustration of DNA after cleavage at the looped region, with the DNA-binding protein remaining attached to the separated DNA ends.

Our recombinases are designed to recognize a safe harbor site in the human genome and introduce a therapeutic payload with high specificity and integrity. The features of our approach include:

Our recombinases are designed to recognize a safe harbor site in the human genome and introduce a therapeutic payload with high specificity and integrity. The features of our approach include:

Our recombinases are designed to recognize a safe harbor site in the human genome and introduce a therapeutic payload with high specificity and integrity. The features of our approach include:

Our recombinases are designed to recognize a safe harbor site in the human genome and introduce a therapeutic payload with high specificity and integrity. The features of our approach include:

Targeted, sequence-specific introduction of therapeutic payloads

Targeted, sequence-specific introduction of therapeutic payloads
Targeted, sequence-specific introduction of therapeutic payloads

Targeted, sequence-specific introduction of therapeutic payloads

Full-length fidelity without exposed double-stranded breaks

Full-length fidelity with no exposed double-stranded breaks
Reproducible, predictable and characterized insertional profile
Full-length fidelity without exposed double-stranded breaks

Reproducible, predictable and characterized insertional profile

Reproducible, predictable and characterized insertional profile
Full-length fidelity without exposed double-stranded breaks

Reproducible, predictable and characterized insertional profile

Capacity for large, complex, multigenic therapeutic payloads

Capacity for large, complex, multigenic therapeutic payloads
Capacity for large, complex, multigenic therapeutic payloads

Capacity for large, complex, multigenic therapeutic payloads

Our Medicines

Our initial focus is to create in vivo CAR-T therapies. Our approach enables precise, durable CAR-T generation inside the body. These CAR-T treatments leverage a cell-targeted lipid nanoparticle (LNP) to deliver therapeutic payloads directly to immune cells in vivo. This approach has the potential to transform patient treatment, improve patient accessibility and redefine what’s possible in medicine.

Illustration of a lipid nanoparticle with a double-layered membrane, containing coiled genetic material and proteins inside, and surface molecules representing targeting binders.
Illustration of a lipid nanoparticle with a double-layered membrane, containing coiled genetic material and proteins inside, and surface molecules representing targeting binders.
Illustration of a lipid nanoparticle with a double-layered membrane, containing coiled genetic material and proteins inside, and surface molecules representing targeting binders.
Illustration of a lipid nanoparticle with a double-layered membrane, containing coiled genetic material and proteins inside, and surface molecules representing targeting binders.
Elegant, therapeutic-grade recombinase:

Refined to encode a durable therapeutic effect

High capacity for therapeutic payloads:

Capable of encoding polyfunctional multi-kb payloads

Targeted lipid nanoparticle delivery:

Elegant, scalable LNP-based in vivo genetic medicines

Our versatile and modular approach has broad therapeutic potential across

Our versatile and modular approach has broad therapeutic potential across

Our versatile and modular approach has broad therapeutic potential across

Illustration of a cluster of pink and white spheres representing cancer cells for oncology applications.
Illustration of a cluster of pink and white spheres representing cancer cells for oncology applications.
Illustration of a cluster of pink and white spheres representing cancer cells for oncology applications.

Oncology

Illustration of a cell with pink antibodies surrounding it, symbolizing autoimmune disease targeting.
Illustration of a cell with pink antibodies surrounding it, symbolizing autoimmune disease targeting.
Illustration of a cell with pink antibodies surrounding it, symbolizing autoimmune disease targeting.

Autoimmune

Illustration of a stylized pink and white liver icon representing genetic disease therapy.
Illustration of a stylized pink and white liver icon representing genetic disease therapy.
Illustration of a stylized pink and white liver icon representing genetic disease therapy.

Genetic Diseases

Illustration of three interconnected spheres containing icons of a brain, heart, and joint, representing broader therapeutic applications beyond the listed categories.
Illustration of three interconnected spheres containing icons of a brain, heart, and joint, representing broader therapeutic applications beyond the listed categories.
Illustration of three interconnected spheres containing icons of a brain, heart, and joint, representing broader therapeutic applications beyond the listed categories.

and beyond

Our Team

Leadership

profile photo of Emile Nuwaysir, Ph.D., Chairman & Chief Executive Officer
Emile Nuwaysir, Ph.D.

Chairman & Chief Executive Officer

profile photo of Emile Nuwaysir, Ph.D., Chairman & Chief Executive Officer
Emile Nuwaysir, Ph.D.

Chairman & Chief Executive Officer

profile photo of Emile Nuwaysir, Ph.D., Chairman & Chief Executive Officer
Emile Nuwaysir, Ph.D.

Chairman & Chief Executive Officer

profile photo of Emile Nuwaysir, Ph.D., Chairman & Chief Executive Officer
Emile Nuwaysir, Ph.D.

Chairman & Chief Executive Officer

Profile photo of Jason Fontenot Ph.D., Chief Scientific Officer
Jason Fontenot, Ph.D.

Chief Scientific Officer

Profile photo of Jason Fontenot Ph.D., Chief Scientific Officer
Jason Fontenot, Ph.D.

Chief Scientific Officer

Profile photo of Jason Fontenot Ph.D., Chief Scientific Officer
Jason Fontenot, Ph.D.

Chief Scientific Officer

Profile photo of Jason Fontenot Ph.D., Chief Scientific Officer
Jason Fontenot, Ph.D.

Chief Scientific Officer

Profile photo of Nicole Heifner, SVP, Finance & Human Resources
Nicole Heifner

SVP, Finance & Human Resources

Profile photo of Nicole Heifner, SVP, Finance & Human Resources
Nicole Heifner

SVP, Finance & Human Resources

Profile photo of Nicole Heifner, SVP, Finance & Human Resources
Nicole Heifner

SVP, Finance & Human Resources

Profile photo of Nicole Heifner, SVP, Finance & Human Resources
Nicole Heifner

SVP, Finance & Human Resources

Profile Photo of Celeste Richardson Ph.D., SVP Immunology
Celeste Richardson, Ph.D.

SVP, Immunology

Profile Photo of Celeste Richardson Ph.D., SVP Immunology
Celeste Richardson, Ph.D.

SVP, Immunology

Profile Photo of Celeste Richardson Ph.D., SVP Immunology
Celeste Richardson, Ph.D.

SVP, Immunology

Profile Photo of Celeste Richardson Ph.D., SVP Immunology
Celeste Richardson, Ph.D.

SVP, Immunology

Profile Photo of Chris Wilson Ph.D., SVP, Genome Engineering Platform
Chris Wilson, Ph.D.

SVP, Genome Engineering

Profile Photo of Chris Wilson Ph.D., SVP, Genome Engineering Platform
Chris Wilson, Ph.D.

SVP, Genome Engineering

Profile Photo of Chris Wilson Ph.D., SVP, Genome Engineering Platform
Chris Wilson, Ph.D.

SVP, Genome Engineering

Profile Photo of Chris Wilson Ph.D., SVP, Genome Engineering Platform
Chris Wilson, Ph.D.

SVP, Genome Engineering

profile photo of Nicole Conlon, PHD, VP, Legal & Intellectual Property
Nicole Conlon, Ph.D., J.D.

VP, Legal & Intellectual Property

profile photo of Nicole Conlon, PHD, VP, Legal & Intellectual Property
Nicole Conlon, Ph.D., J.D.

VP, Legal & Intellectual Property

profile photo of Nicole Conlon, PHD, VP, Legal & Intellectual Property
Nicole Conlon, Ph.D., J.D.

VP, Legal & Intellectual Property

profile photo of Nicole Conlon, PHD, VP, Legal & Intellectual Property
Nicole Conlon, Ph.D., J.D.

VP, Legal & Intellectual Property

profile photo of Cecilia Sun, VP, Business Development & Strategy
Cecilia Sun

VP, Business Development & Strategy

profile photo of Cecilia Sun, VP, Business Development & Strategy
Cecilia Sun

VP, Business Development & Strategy

profile photo of Cecilia Sun, VP, Business Development & Strategy
Cecilia Sun

VP, Business Development & Strategy

profile photo of Cecilia Sun, VP, Business Development & Strategy
Cecilia Sun

VP, Business Development & Strategy

profile photo of srinivasan chollangi, phd, Executive Director, Technical Operations
Srinivas Chollangi, Ph.D.

Executive Director, CMC Tech Ops

profile photo of srinivasan chollangi, phd, Executive Director, Technical Operations
Srinivas Chollangi, Ph.D.

Executive Director, CMC Tech Ops

profile photo of srinivasan chollangi, phd, Executive Director, Technical Operations
Srinivas Chollangi, Ph.D.

Executive Director, CMC Tech Ops

profile photo of srinivasan chollangi, phd, Executive Director, Technical Operations
Srinivas Chollangi, Ph.D.

Executive Director, CMC Tech Ops

Board of Directors

Emile Nuwaysir, Ph.D.

Chairman & Chief Executive Officer,

Stylus Medicine

Nessan Bermingham, Ph.D.

Operating Partner,

Khosla Ventures

John Gustofson

President,

Chugai Venture Fund

Patrick Hsu, Ph.D.

Co-Founder, Arc Institute,

Assistant Professor of Bioengineering, the University of California, Berkeley

Joshua Resnick, M.D.

Partner and Senior Managing Director,

RA Capital

Scientific Founders

Patrick Hsu, Ph.D.

Co-Founder, Arc Institute,

Assistant Professor of Bioengineering, the University of California, Berkeley

Ami S. Bhatt, M.D., Ph.D.

Professor of Medicine & Genetics,

Stanford University

Michael C. Bassik, Ph.D.

Associate Professor of Genetics,

Stanford University

Lacramioara Bintu, Ph.D.

Assistant Professor of Bioengineering,

Stanford University

Our Investors

We are proud to be supported by leading life sciences investors and
biopharmaceutical company venture funds.

RA Capital logo
RA Capital logo
RA Capital logo
RA Capital logo
Lilly logo
Khosla Ventures logo
Khosla Ventures logo
Chugai logo
Chugai logo
Johnson & Johnson logo
Johnson & Johnson logo
Myeloma Investment Fund logo
Myeloma Investment Fund logo
Tachyon Ventures logo
Tachyon Ventures logo
Khosla Ventures logo
Khosla Ventures logo
Chugai logo
Chugai logo
Johnson & Johnson logo
Johnson & Johnson logo
Myeloma Investment Fund logo
Myeloma Investment Fund logo
Tachyon Ventures logo
Tachyon Ventures logo
Khosla Ventures logo
Khosla Ventures logo
Johnson & Johnson logo
Johnson & Johnson logo
Tachyon Ventures logo
Tachyon Ventures logo
Chugai logo
Chugai logo
Myeloma Investment Fund logo
Myeloma Investment Fund logo

We're always interested in innovative, intellectually curious
and collaborative individuals to join our team!

We're always interested in innovative, intellectually curious and collaborative individuals to join our team!

We're always interested in innovative, intellectually
curious and collaborative individuals to join our team!

Stylus Medicine logo

© 2025. Stylus Medicine, Inc.

1400 One Kendall Square, Suite 14-403, Cambridge, MA 02139

Stylus Medicine and the Stylus Medicine logo are registered trademarks with the U.S. Patent & Trademark Office.

Stylus Medicine logo

© 2025. Stylus Medicine, Inc.

1400 One Kendall Square, Suite 14-403, Cambridge, MA 02139

Stylus Medicine and the Stylus Medicine logo are registered trademarks with the
U.S. Patent & Trademark Office.

Stylus Medicine logo

© 2025. Stylus Medicine, Inc.

1400 One Kendall Square, Suite 14-403, Cambridge, MA 02139

Stylus Medicine and the Stylus Medicine logo are
registered trademarks with the U.S. Patent & Trademark Office.

Stylus Medicine logo

© 2025. Stylus Medicine, Inc.

1400 One Kendall Square, Suite 14-403, Cambridge, MA 02139

Stylus Medicine and the Stylus Medicine logo are
registered trademarks with the U.S. Patent & Trademark Office.